The island has surf fishing, pier fishing, rock fishing, and open water fishing if you are out in a boat.
The entire length of the beach offers surf fishing, if you are feeling brave there is fishing off the rock jetties, and good crabbing from them as well.
The North End of the beach offers surf fishing and on the rocks crabbing.
The South End of the beach offers surf fishing and on the rocks crabbing, and fishing and crabbing off the Tybrisa Pier & Pavilion.
On the backside of the island(South End), there is a public pier for fishing and crabbing.
Near the Lazaretto Creek boat ramp there is a the Lazaretto fishing pier, offering fishing and crabbing excitement, and some even fish off the floating dock at the boat ramp, though boaters tend to want to moor up where you are fishing.
On the North side of the Lazaretto Creek Bridge there is a rocky, and oyster shelled area that many enjoy fishing and crabbing from as well.
At the entrance to Fort Pulaski there is fishing and crabbing from both the rocks on either side of the bridge and even off of the bridge, though the bridge fishing is recommened only when the bridge is locked down during non-visiting hours to the fort area.
There is also an area that you can fish on Cockspur Island back behind U.S. Coast Guard Station Tybee from the rocks lining the North Savannah River Channel.